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desvenlafaxine will increase the degree or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by as much as fifty%; no dosage adjustment necessary with desvenlafaxine doses 7 consecutive days straight